abstract：:Apoptosis plays a crucial role in the pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). However, the exact molecular mechanisms underlying neuronal apoptosis in EBI after SAH have not been fully elucidated. The present study showed that EBI induced significantly neuronal apoptosis activ...

journal_title：Molecular neurobiology

authors： Feng D,Wang B,Ma Y,Shi W,Tao K,Zeng W,Cai Q,Zhang Z,Qin H

更新日期：2016-10-01 00:00:00

abstract：:Astrogliosis and microgliosis in hippocampal sclerosis (HS) are widespread and are postulated to contribute to the pro-excitatory neuropathological environment. This study aimed to establish if seizure burden at the time of surgery or post-surgical outcome were correlated with the extent of gliosis in HS. As a seconda...

journal_title：Molecular neurobiology

authors： Johnson AM,Sugo E,Barreto D,Hiew CC,Lawson JA,Connolly AM,Somerville E,Hasic E,Bye AM,Cunningham AM

更新日期：2016-10-01 00:00:00

abstract：:Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...

journal_title：Molecular neurobiology

authors： Schipper S,Aalbers MW,Rijkers K,Swijsen A,Rigo JM,Hoogland G,Vles JS

更新日期：2016-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by intracellular and extracellular protein aggregates, including microtubule-associated protein tau and cleavage product of amyloid precursor protein, β-amyloid (Aβ). Tissue transglutaminase (tTG) is a calcium-dependent enzyme that cross-links proteins forming a γ-glutamyl-ε-l...

journal_title：Molecular neurobiology

authors： Zhang J,Wang S,Huang W,Bennett DA,Dickson DW,Wang D,Wang R

更新日期：2016-10-01 00:00:00

abstract：:Human hGDH2 arose via duplication in the apes and driven by positive selection acquired enhanced catalytic ability under conditions inhibitory to its precursor hGDH1 (common to all mammals). To explore the biological advantage provided by the novel enzyme, we studied, by immunohistochemistry (IHC) and immunofluorescen...

journal_title：Molecular neurobiology

authors： Spanaki C,Kotzamani D,Kleopa K,Plaitakis A

更新日期：2016-10-01 00:00:00

abstract：:The neuroprotective potential of 3,3'-diindolylmethane (DIM), which is a selective aryl hydrocarbon receptor modulator, has recently been shown in cellular and animal models of Parkinson's disease and lipopolysaccharide-induced inflammation. However, there are no data concerning the protective capacity and mechanisms ...

journal_title：Molecular neurobiology

authors： Rzemieniec J,Litwa E,Wnuk A,Lason W,Krzeptowski W,Kajta M

更新日期：2016-10-01 00:00:00

abstract：:Iodine deficiency (ID) during development results in dysfunction of the central nervous system (CNS) and affects psychomotor and motor function. It is worth noting that maternal mild and marginal ID tends to be the most common reason of preventable neurodevelopmental impairment, via a mechanism that has not been eluci...

journal_title：Molecular neurobiology

authors： Dong J,Lei X,Wang Y,Wang Y,Song H,Li M,Min H,Yu Y,Xi Q,Teng W,Chen J

更新日期：2016-09-01 00:00:00

abstract：:Ischemic stroke, caused by obstruction of blood flow to the brain, would initiate microglia activation which contributes to neuronal damage. Therefore, inhibition of microglia-mediated neuroinflammation could be a therapeutic strategy for ischemic stroke. This study was aimed to elucidate the anti-inflammatory effects...

journal_title：Molecular neurobiology

authors： Wu MH,Huang CC,Chio CC,Tsai KJ,Chang CP,Lin NK,Lin MT

更新日期：2016-09-01 00:00:00

abstract：:Glycogen synthase kinase-3β (GSK-3β) is a key element to phosphorylate tau and form neurofibrillary tangles (NFTs) found in tauopathies including Alzheimer's disease (AD). A current topic for AD therapy is focused upon how to prevent tau phosphorylation. In the present study, PKCε activated Akt and inactivated GSK-3β ...

journal_title：Molecular neurobiology

authors： Kanno T,Tsuchiya A,Tanaka A,Nishizaki T

更新日期：2016-09-01 00:00:00

abstract：:Parkinson's disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most common neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to enhance clearance of amyloid-β from the brain of APP-transgenic mice lea...

journal_title：Molecular neurobiology

authors： Fröhlich C,Zschiebsch K,Gröger V,Paarmann K,Steffen J,Thurm C,Schropp EM,Brüning T,Gellerich F,Radloff M,Schwabe R,Lachmann I,Krohn M,Ibrahim S,Pahnke J

更新日期：2016-09-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF), in addition to its neurotrophic action, also possesses antioxidant activities. However, the underlying mechanisms remain to be fully defined. Sestrin2 is a stress-responsive gene implicated in the cellular defense against oxidative stress. Currently, the potential functions of...

journal_title：Molecular neurobiology

authors： Wu CL,Chen SD,Yin JH,Hwang CS,Yang DI

更新日期：2016-08-01 00:00:00

abstract：:Based on current knowledge on the role of the CX3CL1/CX3CR1 axis in the regulation of microglial activation and on the involvement of activated microglia in damaging oligodendrocytes, we hypothesized that CX3CL1/CX3CR1 axis is associated with the development of ischemic oligodendrocyte and white matter injury. We inve...

journal_title：Molecular neurobiology

authors： Wu XM,Liu Y,Qian ZM,Luo QQ,Ke Y

更新日期：2016-08-01 00:00:00

abstract：:It has recently been reported that the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway regulates neuronal differentiation of neural stem cells (NSCs) derived from rats or mice and is essential for the self-renewal of human embryonic stem cells (hESCs). However, the roles of ...

journal_title：Molecular neurobiology

authors： Lee JE,Lim MS,Park JH,Park CH,Koh HC

更新日期：2016-08-01 00:00:00

abstract：:Aromatase inhibitors (AIs) have been commonly used as an effective adjuvant therapy in treatment of breast cancer, especially for menopausal women with estrogen receptor-positive breast cancer. Due to the nature of aromatase, the key enzyme for endogenous estrogen synthesis, inhibitory of aromatase-induced side effect...

journal_title：Molecular neurobiology

authors： Li C,Zhou C,Li R

更新日期：2016-08-01 00:00:00

abstract：:Several plant-derived natural compounds are known to exhibit anti-amyloid aggregation activity which makes them attractive as potential therapies to treat Alzheimer's disease. The mechanisms of their anti-amyloid activity are not well known. In this regard, many natural compounds are known to exhibit direct binding to...

journal_title：Molecular neurobiology

authors： Bu XL,Rao PPN,Wang YJ

更新日期：2016-08-01 00:00:00

abstract：:Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted this meta-analysis to evaluate risk effect of chromosome 4q25 variants on ischemic stroke. We performed the liter...

journal_title：Molecular neurobiology

authors： Sun L,Zhang Z,Xu J,Xu G,Liu X

更新日期：2016-08-01 00:00:00

abstract：:The purpose of this study was to determine whether or not aquaporin-4 (AQP4) gene mutations are related to the pathogenesis of inflammatory demyelinating diseases in the central nervous system. Polymorphisms of AQP4 exons 1-5 were determined by sequencing DNA from 67 patients with central nervous system inflammatory d...

journal_title：Molecular neurobiology

authors： Chu L,Dai Q,Xu Z,He D,Wang H,Wang Q,Zhang Y,Zhu Y,Li Y,Cai G,Slavica K,Allan K

更新日期：2016-07-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT), a ribonucleoprotein, is reported as an important complex, which is required for stability of DNA molecular structure at the rear of the chromosome. Until now, hTERT has been linked to cell immortalization and tumorigenesis. A couple of articles have been published about ...

journal_title：Molecular neurobiology

authors： Li J,Li H,Liu J,Feng B,Feng M,Lv B,Cheng S,Yang X

更新日期：2016-07-01 00:00:00

abstract：:Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an adjuvant/monotherapy for the management of depression. A recent study by our group demonstrated that agmatine induces Nrf2 and protects against corticosterone effects in a hippocampal neuronal cell line. The present study is an extension...

journal_title：Molecular neurobiology

authors： Freitas AE,Egea J,Buendia I,Gómez-Rangel V,Parada E,Navarro E,Casas AI,Wojnicz A,Ortiz JA,Cuadrado A,Ruiz-Nuño A,Rodrigues ALS,Lopez MG

更新日期：2016-07-01 00:00:00

abstract：:Spinal cord injury (SCI) is a traumatic event resulting in disturbances to normal sensory, motor, or autonomic functions, which ultimately impacts a patient's physical, psychological, and social well-being. Until now, no available therapy for SCI can effectively slow down or halt the disease progression. Compared to t...

journal_title：Molecular neurobiology

authors： Yang H,Liu CC,Wang CY,Zhang Q,An J,Zhang L,Hao DJ

更新日期：2016-07-01 00:00:00

abstract：:Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent studies have revealed that hydrogen-rich saline (HS) exerted multiple neuroprotective properties in many neurological diseases including SAH,...

journal_title：Molecular neurobiology

authors： Shao A,Wu H,Hong Y,Tu S,Sun X,Wu Q,Zhao Q,Zhang J,Sheng J

更新日期：2016-07-01 00:00:00

abstract：:Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with multiple functions in the brain during development and in adulthood. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1ß) and IL-18 mediated by caspase-1 which is under t...

journal_title：Molecular neurobiology

authors： Zendedel A,Johann S,Mehrabi S,Joghataei MT,Hassanzadeh G,Kipp M,Beyer C

更新日期：2016-07-01 00:00:00

abstract：:Evidence indicates that neural stem cells (NSCs) can ameliorate cerebral ischemia in animal models. In this study, we investigated the mechanism underlying one of the neuroprotective effects of NSCs: tunneling nanotube (TNT) formation. We addressed whether the control of cell-to-cell communication processes between NS...

journal_title：Molecular neurobiology

authors： Wang X,Yu X,Xie C,Tan Z,Tian Q,Zhu D,Liu M,Guan Y

更新日期：2016-05-01 00:00:00

abstract：:The association between Alzheimer's disease and uric acid levels had gained great interest in recent years, but there was still lack of definite evidence. A systematic review and meta-analysis of relevant studies was performed to comprehensively estimate the association. Relevant studies published before October 26, 2...

journal_title：Molecular neurobiology

authors： Du N,Xu D,Hou X,Song X,Liu C,Chen Y,Wang Y,Li X

更新日期：2016-05-01 00:00:00

abstract：:Huntington's disease (HD) is a movement disorder characterized by the early selective degeneration of striatum. For motor control, the striatum receives excitatory inputs from multiple brain regions and projects the information to other basal ganglia nuclei. Despite the pathological importance of the striatal degenera...

journal_title：Molecular neurobiology

authors： Kim D,Jeon J,Cheong E,Kim DJ,Ryu H,Seo H,Kim YK

更新日期：2016-05-01 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1/KDM1A) plays an important role in complex cellular processes such as differentiation, proliferation, apoptosis, and cell cycle progression. It has recently been demonstrated that during development, downregulation of LSD1 inhibits cell proliferation, modulates the expression of cell...

journal_title：Molecular neurobiology

authors： He Y,Tang D,Cai C,Chai R,Li H

更新日期：2016-05-01 00:00:00

abstract：:This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 ...

journal_title：Molecular neurobiology

authors： Wu W,Guan Y,Xu K,Fu XJ,Lei XF,Lei LJ,Zhang ZQ,Cheng Y,Li YQ

更新日期：2016-05-01 00:00:00

abstract：:A great deal of attention has been paid to neuroprotective therapies for cerebral ischemic stroke. Our two recent clinical trials showed that ginsenoside Rd (Rd), a kind of monomeric compound extracted from Chinese herbs, Panax ginseng and Panax notoginseng, was safe and efficacious for the treatment of ischemic strok...

journal_title：Molecular neurobiology

authors： Zhang G,Xia F,Zhang Y,Zhang X,Cao Y,Wang L,Liu X,Zhao G,Shi M

更新日期：2016-05-01 00:00:00

abstract：:Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of ...

journal_title：Molecular neurobiology

authors： Suvarna Y,Maity N,Shivamurthy MC

更新日期：2016-05-01 00:00:00

abstract：:Disturbance of neuregulin-1β/ErbB4 signaling is considered to be associated with brain ischemia, but the mechanisms of this disruption are largely unknown. In the present study, we provide evidence that degradation of ErbB4 is involved in neuronal cell death in response to ischemia. Our data showed that the applicatio...

journal_title：Molecular neurobiology

authors： Lu YM,Gao YP,Tao RR,Liao MH,Huang JY,Wu G,Han F,Li XM

更新日期：2016-05-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron death in the substantia nigra (SN) and subsequent striatal adaptations. Mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP) are widely used as a model for PD. To assess the validity of the MPTP mouse model for PD p...

journal_title：Molecular neurobiology

authors： Klemann CJHM,Martens GJM,Poelmans G,Visser JE

更新日期：2016-04-01 00:00:00

abstract：:The neuronal circuit remodels during development as well as in human neuropathologies such as epilepsy. Neurite outgrowth is an obligatory step in these events. We recently reported that alterations in the phosphorylation state of an axon specification/guidance protein, the collapsin response mediator protein 2 (CRMP2...

journal_title：Molecular neurobiology

authors： Moutal A,François-Moutal L,Perez-Miller S,Cottier K,Chew LA,Yeon SK,Dai J,Park KD,Khanna M,Khanna R

更新日期：2016-04-01 00:00:00

abstract：:The protective and therapeutic mechanism of bee venom acupuncture (BVA) in neurodegenerative disorders is not clear. We investigated whether treatment with BVA (0.25 and 0.8 mg/kg) at the Zusanli (ST36) acupoints, located lateral from the anterior border of the tibia, has a beneficial effect in a myelin basic protein ...

journal_title：Molecular neurobiology

authors： Lee MJ,Jang M,Choi J,Lee G,Min HJ,Chung WS,Kim JI,Jee Y,Chae Y,Kim SH,Lee SJ,Cho IH

更新日期：2016-04-01 00:00:00

abstract：:Maternal hypothyroxinemia can induce neurodevelopmental impairments in the developing fetus. We here review recent studies on the epidemiology and molecular mechanisms associated with this important public health issue. In 2011, the American Thyroid Association defined maternal hypothyroxinemia as low serum free thyro...

journal_title：Molecular neurobiology

authors： Min H,Dong J,Wang Y,Wang Y,Teng W,Xi Q,Chen J

更新日期：2016-04-01 00:00:00

abstract：:Abnormal hippocampal neurogenesis is a prominent feature of temporal lobe epilepsy (TLE) models, which is thought to contribute to abnormal brain activity. Stromal cell-derived factor-1 (SDF-1) and its specific receptor CXCR4 play important roles in adult neurogenesis. We investigated whether treatment with the CXCR4 ...

journal_title：Molecular neurobiology

authors： Song C,Xu W,Zhang X,Wang S,Zhu G,Xiao T,Zhao M,Zhao C

更新日期：2016-04-01 00:00:00

abstract：:Hypertension is one of the co-morbid conditions for stroke and profoundly increases its incidence. Angiotensin II (AngII) is shown to be at the center stage in driving the renin angiotensin system via activation of angiotensin 1 receptor (AT1R). This makes the AT1R gene one of the candidates whose differential regulat...

journal_title：Molecular neurobiology

authors： Jain S,Tulsulkar J,Rana A,Kumar A,Shah ZA

更新日期：2016-04-01 00:00:00

abstract：:Protein aggregation is involved in a variety of diseases. Alteration of the aggregation pathway, either to produce less toxic structures or to increase aggregate clearance, is a promising therapeutic route. Both active and passive immunization has been used for this purpose. However, the mechanism of action of antibod...

journal_title：Molecular neurobiology

authors： Breydo L,Morgan D,Uversky VN

更新日期：2016-04-01 00:00:00

abstract：:Since melamine was illegally added to raw milk for increasing the apparent protein content, such a scandal has not been quite blown out. Previous studies showed that melamine induced apoptosis and oxidative damage in both in vivo and in vitro experiments. It is well known that autophagy is closely related to oxidative...

journal_title：Molecular neurobiology

authors： Wang H,Gao N,Li Z,Yang Z,Zhang T

更新日期：2016-04-01 00:00:00

abstract：:Multiple players are involved in motor and sensory dysfunctions after spinal cord injury (SCI). Therefore, therapeutic approaches targeting these various players in the damage cascade hold considerable promise for the treatment of traumatic spinal cord injury. Soluble epoxide hydrolase (sEH) is an endogenous key enzym...

journal_title：Molecular neurobiology

authors： Chen X,Chen X,Huang X,Qin C,Fang Y,Liu Y,Zhang G,Pan D,Wang W,Xie M

更新日期：2016-04-01 00:00:00

abstract：:P2C-type ATPases are a subfamily of P-type ATPases comprising Na(+)/K(+)-ATPase and H(+)/K(+)-ATPase. Na(+)/K(+)-ATPase is ubiquitously expressed and has been implicated in several neurological diseases, whereas H(+)/K(+)-ATPase is found principally in the colon, stomach, and kidney. Both ATPases have two subunits, α ...

journal_title：Molecular neurobiology

authors： Retamales-Ortega R,Vio CP,Inestrosa NC

更新日期：2016-03-01 00:00:00